Is IVF safe? What is the best age to go for IVF?

IVF aids in fertilization, embryo formation, and implantation, allowing a woman to become pregnant.

IVF is widely used by closely supervised hospitals under the watchful eye of the HFEA for a variety of purposes (Human Fertility and Embryology Association). IVF is a common type of assisted reproduction for infertile couples, same-sex couples, and single mothers who choose to start a family.

The global in vitro fertilization services industry was worth $12,506 million in 2018, and is expected to be worth $25,563 million by 2026, with a CAGR of 9.3% from 2019 to 2026.

Infertility therapy with IVF

IVF allows infertile couples to become pregnant, an achievement that has allowed countless couples to experience the joys of a normal, stable conception, childbirth, and all that follows. IVF's benefits are better espoused by the numerous couples in the UK alone who have had their lives transformed by the treatment, even though it is surrounded by some controversy.

If male infertility is a concern, IVF can help, particularly when combined with another technique called ICSI (Intra-cytosolic Sperm Injection).

Why IVF?

Patients should consider fertility drugs and artificial insemination before undergoing IVF because they are less invasive. If one of the partners has one of the following requirements, IVF should be considered.

Irregular Fallopian Tube
Ovarian failure
Unregulated Ovulation
Endometriosis
Low sperm count
Genetics

What is the appropriate age for IVF treatment?

According to a study of 290 fertility clinics, 37% of women under the age of 35 had active IVF implantation. For women aged 35-37, the percentage dropped to 31%. Furthermore, only 21% of women between the ages of 38 and 40 are capable of conceiving artificially. Women under the ages of 41 and 42 had a lower rate of 11 percent, and women above the age of 42 had a lower rate of 4 percent.

As a result, the overall IVF pregnancy success rate is 27 percent. Women under the age of 35 are the most likely to have favorable results.

The inherent boundaries of fertility for women have been altered in several ways. Women who have reached menopause will still get pregnant with the assistance of hormone therapies and donation.

Since the fetus' morbidity rises with the mother's age, the woman must be informed about all the complications associated with an older pregnancy.

According to the Indian Council of Medical Research (ICMR), the mother "shall be a stable woman (as decided by medical and psychological examination) with natural genitalia (as determined by physical examination) and uterine cavity (as determined by hysterosalpingography)."

When it comes to receiving donated embryos, there is no upper age limit for IVF in India, according to the Ministry of Health, Government of India, 2005 guidelines. However, the 2017 ICMR bill for Assisted Reproductive Technology proposes a 45-year-old upper age limit for women.

IVF success rates by age

The “age” of the woman receiving IVF treatment is one of the most influential causes that is most likely to influence the success rate of the whole IVF treatment. Since long, age has played a significant role in women's births, whether it is a normal or artificial birth. Similarly, it plays an important part in IVF therapy. While it has been shown that women in their forties and fifties are more likely to have higher IVF success rates, women in their forties and fifties are more likely to have lower IVF success rates. We'll look into that further based on the age group.

IVF success rates under 35

Women under 35, particularly those in their 20s, are said to have higher success rates in terms of age because this is when they are most fertile. Women who don't have any known fertility problems have a 20% pregnancy success rate, but if they have any infertility issues, such as a lack of embryos, genetic disorder, partner infertility, or a same-sex partnership, they can opt for IVF, which has the following success rates, according to CDC research:

Women under the age of 35 have a greater success rate than women over the age of 35 who are receiving IVF therapy.
If a woman has never been pregnant before and is under the age of 35, she is more likely to conceive in 32 percent of cases.
If a woman has already had a child, there is a 37 percent likelihood that an IVF cycle would succeed and result in a healthy pregnancy before the age of 35.
If a woman is in her twenties, she has a 34% risk of having two or more children after an IVF period.

IVF Success rates over 40

Women over the age of 40 are less able to conceive; in previous decades, it was almost impossible for women over the age of 40 to have a baby. But, thanks to advanced developments and advances such as assisted reproductive technology (ART), it is now possible for women over the age of 40 to have a baby and experience motherhood even as they approach menopause.

According to studies conducted by the Centers for Disease Control and Prevention (CDC) and the Society for Assisted Reproductive Technology (SART), if fresh embryos are used for therapy, IVF success rates above 40 are as follows:

For women over 40, IVF has a 20% success rate and live birth has a 14% success rate.
IVF cycles have a 15% success rate for 41, and live birth has a 10% success rate.
For 42, the IVF period and live birth rates are each 12% and 7%.
After 43 years, the percentage drops to 8%, with just 3% of pregnancies ending in a stable birth.
There is a 6% risk of IVF resulting in conception and a 3% chance of a live birth for 44-year-olds.
Finally, women over 45 have only a 3% risk of becoming pregnant by IVF and a 1% chance of having a live child.

IVF success rates in India

India has made significant progress in the fields of medicine and technology. IVF therapy has been available in India for years and has been generally embraced and followed by couples with infertility issues. According to the Obstetrics and Gynecology department of one of India's most prestigious hospitals, the All India Institute of Medical Sciences in New Delhi, IVF performance rates in India range from 30-35 percent (AIIMS). The success rates of the procedure will improve by up to 40% during a successful run. The (AIIMS) calculations of success ratios are strongly comparable with many other countries, with the percentage of women under 35 years of age being very high.

How does IVF work?

IVF helps semen fertilize an egg and the fertilized egg implant in your uterus by combining medications and surgical procedures.

To begin, you must take medicine that causes some of your eggs to mature and become fertile. The doctor then removes the eggs from your body and mixes them with semen in a lab to aid the fertilization of the eggs. They will then implant one or two fertilized eggs (embryos) into the uterus. If any of the embryos implant in the lining of your uterus, you will become pregnant.

Side effects of IVF?