What is Second IVF Success Rate?
When success rates for IVF were low, the emphasis was on getting to 'the baby.' Having a second child was hardly contemplated. Nowadays, couples recognise how important it is to have a second child once the first one succeeds. Women who used assisted reproductive technology (ART) to birth their first child and then returned for a second child had a better than even chance of becoming pregnant again, according to a large population-based research. Women who recommenced ART therapy with previously frozen embryos had a cumulative live birth rate ranging from 61% to 88% after six full cycles, depending on assumptions made about the chances of success in women who had stepped out of treatment. The cumulative live birth rates for women who began in vitro fertilisation (IVF) for their second child with fresh embryos ranged from 51% to 70%.
Women who were more likely to have a second live birth during their second ART therapy were younger, had frozen embryos from their first IVF treatment, had a shorter interval between the birth of their first child and the second treatment, and got pregnant in the first few cycles.
Second IVF attempts had somewhat lower success rates than first IVF attempts. Couples with the optimal egg quality are more likely to conceive on their first try, but this is partially offset by the possibility of learning from the first failed cycle and making modifications to improve success for the second in vitro fertilisation attempt.
Women who utilised a frozen embryo from a prior treatment had a live birth rate of 43.4 percent in the first full cycle, compared to 31.3 percent for women who started a fresh ovarian stimulation cycle. Live birth rates were similar among women under 30 who began their second treatment with previously frozen or fresh embryos. However, older women had a higher rate of live births when frozen embryos were used.
Success rates for IVF and a woman’s age
According to a study, after a live delivery by IVF, a woman's chances of having another ART baby are between 51 and 88 % after six cycles. The success rate is affected by whether the cycle uses a frozen embryo (from a previous cycle) or a fresh activated cycle. After just one cycle, the chances of having a baby are 43.4 % (using frozen embryos) or 31.3 %(using fresh embryos).
The study also found that as women's age increased, their chances of success decreased. After three cycles of treatment, live birth rates in women aged 40 to 44 varied from 38 to 55 % when utilising a frozen embryo and 20 to 25 % when using fresh embryos from a new stimulation cycle.
Second IVF Success Rate
Though you were successful with IVF before doesn't imply success again. Given your prior experience, physicians believe your odds of success with IVF are better. Given your age, it's possible that you'll have to try multiple times before achieving IVF success. Trying for a second child via IVF shortly after your first baby is born increases your chances of getting pregnant.
However, when the first child is born, a few parents consider having another. The first IVF cycle may be emotionally exhausting, and couples are relieved to have it over with. If you've had success with one IVF baby, you'll be lot more relaxed and hopeful the second time around. It's best to start planning your second IVF baby as soon as possible to improve your chances of a successful second IVF cycle after the first IVF baby. It is considerably simpler to undergo IVF for a second child since you have already gone through the process and are familiar with all of the dos and don'ts.
Within each age group, the chances of pregnancy through IVF remain the same for the first 3-4 attempts, and while the chances of pregnancy fall slightly after that, pregnancies are still seen in patients on their fifth or sixth try. In fact, according to a recent research, the chances of conceiving a baby after up to six cycles of IVF were good (up to 86% for women under 35 and up to 42 % for women over 40).
Women aged 35-39 had a 22% lower chance of having a second ART-conceived baby if they recommenced therapy using a frozen embryo from a previous cycle, and a 50% lower chance if they recommenced treatment with a new cycle and a fresh embryo as compared to women younger than 30 years. Having only one cycle and a single embryo transfer to obtain a first live delivery, enhanced their odds of a successful second pregnancy, where infertility caused by issues affecting the male spouse.
Success rate with ART treatment
After six cycles, the CLBR varied from 61% (conservative estimate) to 88% (ideal estimate) for those who utilised a frozen embryo from the egg retrieval cycle that resulted in their first child. The CLBR varied from 51% to 70% among women who underwent a new stimulation cycle and utilised a fresh embryo. Overall, following their initial embryo transfer operation, 43% of women who resume therapy using one of the frozen embryos from a prior stimulation session will conceive a baby. After six cycles, between 61% and 88% of these women will have a baby. After their first cycle, 31% of individuals who resume therapy with a new stimulation cycle and a fresh embryo transfer will have a baby, and between 51% and 70% will have a baby after six cycles.
Though it was found biologically, that success rates decreased with female age, the researchers discovered that after three cycles of treatment, the conservative and optimal CLBRs in women aged 40 to 44 years were 38 percent and 55 percent in those who started with a frozen embryo. It was found to be 20 percent and 25 percent in those who restarted with a new stimulated cycle and fresh embryos.
Conclusion
The need for only one cycle, a single embryo transfer for the first IVF-conceived baby, and infertility originating in issues affecting the male spouse were all reported as variables favourably impacting the odds for a successful second pregnancy. The findings highlight the importance of treating ART as a course of therapy rather than a single cycle of treatment: if couples don't get pregnant in the first cycle, it's extremely likely to happen in the next. It is, nevertheless, advisable not to wait too long, particularly if a new stimulation cycle is required. Individual prognostic variables that may impact a woman's likelihood of IVF success, such as infertility length, BMI, and ovarian reserve, are not taken into consideration in this study. The numbers are useful as population estimates, but numerous individual circumstances, such as the duration and cause of infertility, influence a woman's chances of ART success. These findings can be utilised to help patients, but keep in mind that these are population estimates, and each couple is distinct. The study does not account for all individual characteristics that influence a woman's likelihood of ART success, such as infertility duration and BMI. It would also assist patients in viewing their IVF treatment as a continuous process rather than a series of failed or successful cycles, by recognising that many women need several cycles before being able to take home a baby. The choice to begin or continue ART therapy should be made jointly by the fertility physician and the patient, taking into account all medical and non-medical variables.
Sources:
https://www.medpagetoday.com/endocrinology/infertility/86402https://advancedfertility.com/2020/09/18/ivf-failed-what-to-do-next-after-a-failed-cycle-in-order-to-have-success-with-the-second-ivf-attempt/
https://www.cityfertility.com.au/new-study-reveals-good-chances-for-second-baby-via-ivf/
https://www.eurekalert.org/pub_releases/2020-05/esoh-way050620.php
https://www.bionews.org.uk/page_149539
https://www.medicoverfertility.in/blog/planning-second-ivf-baby,113,n,5475
https://uscfertility.org/ivf-first-dont-succeed-try/